Friday, October 4, 2013

Big Troubles Associated with Antidepressants

I love Dr. Mercola's newsletter in part because he is so outspoken and unafraid of making waves.  (I also think he has good lawyers because he has been sued by pharma companies who like to keep a lid on this kind of perspective!)

This is a short excerpt from a Mercola article:
  • Antidepressant-induced violence and homicide is an international problem, but it is particularly apparent in the US due to the widespread use (and misuse) of these drugs
  • 31 commonly-prescribed drugs are disproportionately associated with cases of violent acts. Five of the top 10 most violence-inducing drugs are antidepressants. Commonly used ADHD drugs are also on the list
  • Research has found that one in every 250 subjects taking Paxil or Prozac were involved in a violent episode. In a study group of 25,000 people, this included 31 assaults and one homicide
http://articles.mercola.com/sites/articles/archive/2013/10/03/antidepressant-side-effects.aspx?e_cid=20131003Z1_DNL_art_1&utm_source=dnl&utm_medium=email&utm_content=art1&utm_campaign=20131003Z1

....It is interesting to me that St. John's Wort is largely prescribed in Europe for depression and seems to be so uncommon here as far as prescriptions go.  Also the work of Daniel Amen breaks depression down into many types, some of them are not due to low serotonin.  Interestingly there is a simple urine test for a neurotransmitter profile ($90 without insurance)--but how many doctors don't give it to their patients before prescribing antidepressants.  

What if that patient is sleeping a lot and low energy becasue of adrenal fatigue or sub clinical low thyroid (low normal range, which some doctors think is too low) and not depression?  What if the neurotransmitter test is not given, and the patient has HIGH serotonin (see the work of Ray Peat)--if a patient is high in serotonin the absolute last thing they need (according to Ray) is to boost their serotonin.  This is why I am glad for people like Mercola who offer a cautionary perspective on antidepressants.


A Votre Sante, (Here's To Your Health,)  Alix

Segmented Sleep Normal?

I found this very interesting article about sleep online (here is a slightly abbreviated version.)

 
The myth of the eight-hour sleep

By Stephanie Hegarty BBC World Service

We often worry about lying awake in the middle of the night - but it could be good for you. A growing body of evidence from both science and history suggests that the eight-hour sleep may be unnatural.

In the early 1990s, psychiatrist Thomas Wehr conducted an experiment in which a group of people were plunged into darkness for 14 hours every day for a month.

It took some time for their sleep to regulate but by the fourth week the subjects had settled into a very distinct sleeping pattern. They slept first for four hours, then woke for one or two hours before falling into a second four-hour sleep.

Though sleep scientists were impressed by the study, among the general public the idea that we must sleep for eight consecutive hours persists.

In 2001, historian Roger Ekirch of Virginia Tech published a seminal paper, drawn from 16 years of research, revealing a wealth of historical evidence that humans used to sleep in two distinct chunks.

His book At Day's Close: Night in Times Past, published four years later, unearths more than 500 references to a segmented sleeping pattern - in diaries, court records, medical books and literature, from Homer's Odyssey to an anthropological account of modern tribes in Nigeria.

Much like the experience of Wehr's subjects, these references describe a first sleep which began about two hours after dusk, followed by waking period of one or two hours and then a second sleep.

"It's not just the number of references - it is the way they refer to it, as if it was common knowledge," Ekirch says.

During this waking period people were quite active. They often got up, went to the toilet or smoked tobacco and some even visited neighbours. Most people stayed in bed, read, wrote and often prayed. Countless prayer manuals from the late 15th Century offered special prayers for the hours in between sleeps.

[The article gives examples of segmented sleep references from literature]

  • "He knew this, even in the horror with which he started from his first sleep, and threw up the window to dispel it by the presence of some object, beyond the room, which had not been, as it were, the witness of his dream." Charles Dickens, Barnaby Rudge (1840)
  • "Don Quixote followed nature, and being satisfied with his first sleep, did not solicit more. As for Sancho, he never wanted a second, for the first lasted him from night to morning." Miguel Cervantes, Don Quixote (1615)
  • "And at the wakening of your first sleepe You shall have a hott drinke made, And at the wakening of your next sleepe Your sorrowes will have a slake." Early English ballad, Old Robin of Portingale
  • The Tiv tribe in Nigeria employ the terms "first sleep" and "second sleep" to refer to specific periods of the night

And these hours weren't entirely solitary - people often chatted to bed-fellows or had sex.

A doctor's manual from 16th Century France even advised couples that the best time to conceive was not at the end of a long day's labour but "after the first sleep", when "they have more enjoyment" and "do it better".

Ekirch found that references to the first and second sleep started to disappear during the late 17th Century. This started among the urban upper classes in northern Europe and over the course of the next 200 years filtered down to the rest of Western society.

By the 1920s the idea of a first and second sleep had receded entirely from our social consciousness.

He attributes the initial shift to improvements in street lighting, domestic lighting and a surge in coffee houses - which were sometimes open all night. As the night became a place for legitimate activity and as that activity increased, the length of time people could dedicate to rest dwindled.

In his new book, Evening's Empire, historian Craig Koslofsky puts forward an account of how this happened.

"Associations with night before the 17th Century were not good," he says. The night was a place populated by people of disrepute - criminals, prostitutes and drunks.

"Even the wealthy, who could afford candlelight, had better things to spend their money on. There was no prestige or social value associated with staying up all night."


That changed in the wake of the Reformation and the counter-Reformation. Protestants and Catholics became accustomed to holding secret services at night, during periods of persecution. If earlier the night had belonged to reprobates, now respectable people became accustomed to exploiting the hours of darkness.

This trend migrated to the social sphere too, but only for those who could afford to live by candlelight. With the advent of street lighting, however, socialising at night began to filter down through the classes.

In 1667, Paris became the first city in the world to light its streets, using wax candles in glass lamps. It was followed by Lille in the same year and Amsterdam two years later, where a much more efficient oil-powered lamp was developed.

London didn't join their ranks until 1684 but by the end of the century, more than 50 of Europe's major towns and cities were lit at night.

Night became fashionable and spending hours lying in bed was considered a waste of time.

"People were becoming increasingly time-conscious and sensitive to efficiency, certainly before the 19th Century," says Roger Ekirch. "But the industrial revolution intensified that attitude by leaps and bounds."

Strong evidence of this shifting attitude is contained in a medical journal from 1829 which urged parents to force their children out of a pattern of first and second sleep.

A small city like Leipzig in central Germany employed 100 men to tend to 700 lamps.

"If no disease or accident there intervene, they will need no further repose than that obtained in their first sleep, which custom will have caused to terminate by itself just at the usual hour.

"And then, if they turn upon their ear to take a second nap, they will be taught to look upon it as an intemperance not at all redounding to their credit."

Today, most people seem to have adapted quite well to the eight-hour sleep, but Ekirch believes many sleeping problems may have roots in the human body's natural preference for segmented sleep as well as the ubiquity of artificial light.

This could be the root of a condition called sleep maintenance insomnia, where people wake during the night and have trouble getting back to sleep, he suggests.

The condition first appears in literature at the end of the 19th Century, at the same time as accounts of segmented sleep disappear.

"For most of evolution we slept a certain way," says sleep psychologist Gregg Jacobs. "Waking up during the night is part of normal human physiology."

The idea that we must sleep in a consolidated block could be damaging, he says, if it makes people who wake up at night anxious, as this anxiety can itself prohibit sleeps and is likely to seep into waking life too.

Every 60-100 minutes we go through a cycle of four stages of sleep

  • Stage 1 is a drowsy, relaxed state between being awake and sleeping - breathing slows, muscles relax, heart rate drops
  • Stage 2 is slightly deeper sleep - you may feel awake and this means that, on many nights, you may be asleep and not know it
  • Stage 3 and Stage 4, or Deep Sleep - it is very hard to wake up from Deep Sleep because this is when there is the lowest amount of activity in your body
  • After Deep Sleep, we go back to Stage 2 for a few minutes, and then enter Dream Sleep - also called REM (rapid eye movement) sleep - which, as its name suggests, is when you dream

In a full sleep cycle, a person goes through all the stages of sleep from one to four, then back down through stages three and two, before entering dream sleep

Russell Foster, a professor of circadian [body clock] neuroscience at Oxford, shares this point of view.

"Many people wake up at night and panic," he says. "I tell them that what they are experiencing is a throwback to the bi-modal sleep pattern."

But the majority of doctors still fail to acknowledge that a consolidated eight-hour sleep may be unnatural.

"Over 30% of the medical problems that doctors are faced with stem directly or indirectly from sleep. But sleep has been ignored in medical training and there are very few centres where sleep is studied," he says.

Jacobs suggests that the waking period between sleeps, when people were forced into periods of rest and relaxation, could have played an important part in the human capacity to regulate stress naturally.

In many historic accounts, Ekirch found that people used the time to meditate on their dreams.

"Today we spend less time doing those things," says Dr Jacobs. "It's not a coincidence that, in modern life, the number of people who report anxiety, stress, depression, alcoholism and drug abuse has gone up."

So the next time you wake up in the middle of the night, think of your pre-industrial ancestors and relax. Lying awake could be good for you.
 
......Very interesting article, I had never heard of segmented sleep until I read this.
 
A Votre Sante (Here's To Your Health,) Alix

 
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